039 - Superoxide anion production and mitochondrial dysfunction in Maple Syrup Urine Disease: An ex vivo study on human neonate skin fibroblast cultures.
041 - Neurobehavioral Deficits and Macrophage Mitochondrial Impairment Occur with Distinct Sex-specificities in the Ndufa1S55A Mouse Model of Moderate Complex I Deficiency
Location: Congressional/Senate/South American
Speaker: Daniel Freeman – University of Maryland School of Medicine
Metabolism/Bioenergetics
4:15 PM - 6:15 PM US EST
043 - Metabolic remodeling as a mediator of fibroblast differentiation and function
064 - Nitrite and nitrate levels in postmortem biological samples following suspected suicide between 2019-2024: evidence highlighting a need for urgent action
068 - Inhibition of Xanthine Oxidase (XO) by Febuxostat Protects Against Nano-TiO2 Fetal Growth Restriction but Decreases Implantation Number in Sprague Dawley Dams
069 - Effects of PFOS on Pancreatic Function Are Modulated by Nrf2a in Zebrafish (Danio rerio)
Location: Congressional/Senate/South American
Speaker: Marjorie Graham – Unmiversity of Massachusetts Amherst
Environmental Toxicology/Pharmacology
4:15 PM - 6:15 PM US EST
070 - Combination Antiretroviral Therapy: Impacts of Cardiovascular Health During Pregnancy and the Postpartum Period
Location: Congressional/Senate/South American
Speaker: Julia House – National Institute of Environmental Health Sciences
Environmental Toxicology/Pharmacology
4:15 PM - 6:15 PM US EST
073 - Trapping DNA radicals with 5,5-dimethyl-1-pyrroline N-oxide reduces mutagenesis: a mechanistic study in an in vitro model of pulmonary neutrophilic inflammation
Location: Congressional/Senate/South American
Speaker: Dario C. Ramirez, PhD M.Sc. – National University of San Luis - National Bureau of Science and Technology-San Luis
Environmental Toxicology/Pharmacology
4:15 PM - 6:15 PM US EST
074 - Development of an LC-MS/MS Method for the Quantitation of 2-Iminobiotin in Cerebrospinal Fluid and Brain Tissue from a Neonatal Piglet Model of Acute-Hypoxia
Location: Congressional/Senate/South American
Speaker: Anibal Reyes – Universidad de la República
Environmental Toxicology/Pharmacology
4:15 PM - 6:15 PM US EST
075 - One-time or multiple PM2.5 exposure triggers behavioral abnormality among rodents via neurological inflammation and redox stress
Location: Congressional/Senate/South American
Speaker: Jun Wang – Hubei University of Technology
Environmental Toxicology/Pharmacology
4:30 PM - 5:30 PM US EST
Featured Poster Symposia
4:30 PM - 5:30 PM US EST
Featured Poster Symposia
Location: Foyer
4:30 PM - 4:36 PM US EST
007 - Extracellular Superoxide Dismutase R213G Variant Protects Against Lung Fibrosis by Activating AMPK and Limiting Lipid Accumulation
Mitochondrial Resilience Enables Extraordinary Hypoxia Tolerance in Long-Lived Species
Location: Presidential Ballroom
Oral Presenter: Perinur Bozaykut Eker, PhD – Jean Mayer USDA Human Nutrition Center on Aging, Tufts University
2:15 PM - 4:15 PM US EST
8 - SYMPOSIUM SESSION: Papers of the Year / FRBM, RB, ARRES, RBC
2:15 PM - 4:15 PM US EST
SYMPOSIUM SESSION: Papers of the Year / FRBM, RB, ARRES, RBC
Location: Federal AB
2:15 PM - 2:45 PM US EST
2024 Paper of the Year - Free Radical Biology and Medicine: Mitochondria-tau Association Promotes Cognitive Decline and Hippocampal Bioenergetic Deficits During Aging
2024 Paper of the Year - Redox Biology: Aerobic Exercise Attenuates LPS-induced Cognitive Dysfunction by Reduxing Oxidative Stress, Glial Activation, and Neuroinflammation
2024 Paper of the Year - Redox Biochemistry & Chemistry: Lactoperoxidase Catalytically Oxidize Hydrogen Sulfide via Intermediate Formation of Sulfheme Derivatives
080 - Extramitochondrial superoxide dismutase-2 (SOD2) as a vulnerability and pharmacologic target to suppress the dissemination of circulating breast cancer cells.
Location: Congressional/Senate/South American
Speaker: Marcelo Bonini – H. Lee Moffitt Comprehensive Cancer Center
Cancer
4:15 PM - 6:15 PM US EST
081 - Radiation-induced mitochondrial ROS and TFAM-enriched EVs promote cancer regrowth and CD45⁺ cell infiltration in prostate cancer
124 - Cysteinyl-tRNA Synthetase Mediated Cysteine Persulfide Biosynthesis and Redox Regulation in the Human Enteric Protozoan Parasite Entamoeba histolytica
136 - Role of histidine residues on Inhibition of PGHS-2 by Nitroarachidonic Acid. Effects of heme binding on enzymatic activity and termal stability of enzyme-inhibitor complexes
Location: Congressional/Senate/South American
Speaker: Irene Wood – Facultad de Medicina, Universidad de la República
Chemical Biology
4:15 PM - 6:15 PM US EST
137 - Toward localization of cellular oxidants using chemoproteomics – mechanistic study of phenolic probes for peroxynitrite-dependent protein labeling
Cu Transport Proteins as Novel Therapeutic Targets for Cu-dependent Brain Endothelial Barrier Dysfunction and Cuproptosis linked to Alzheimer’s Disease
Location: Federal AB
Oral Presenter: Md. Selim Hossain, PhD – Medical College of Georgia at Augusta University
3:55 PM - 4:15 PM US EST
KCTD12 redox state as a determinant and therapeutic target in pulmonary remodeling
Location: Federal AB
Oral Presenter: Daniel de Jesus, PhD – Willian Harvey Research Institute/Queen Mary University of London
2:15 PM - 4:15 PM US EST
12 - SYMPOSIUM SESSION: Redox Protein Modifications: From Biochemistry to Physiochemistry to Physiology
Co-Chair: Marcelo Bonini – H. Lee Moffitt Comprehensive Cancer Center
156 - Assessment of the participation of sulfhydryl proteins in the glutathione peroxidase mimicry of diphenyl diselenide in the presence of thiol alkylating agent.
157 - Effect OF m-trifluoromethyl- attachment on the glutathione peroxidase mimicry and antioxidant actions of diphenyl diselenide: Essential thiols of
electrogenic sodium pump as a mechanistic component
169 - NoxO1 as Novel Regulator of Intracellular Trafficking and Endosomal Dynamics
Location: Congressional/Senate/South American
Speaker: Maureen Hebchen – Goethe University/Institute for cardiovascular physiology
Redox/Cell Signaling
4:15 PM - 6:15 PM US EST
170 - Proteomic Characterization of Glucose-Induced Redox Signaling in Human Pancreatic β-cells
Location: Congressional/Senate/South American
Speaker: Blanka Holendova – Institute of Physiology, Czech Academy of Sciences
Redox/Cell Signaling
4:15 PM - 6:15 PM US EST
172 - A link between the mitochondrial and cytosolic quality control revealed through analysis of amyotrophic lateral sclerosis-associated mutations in OMA1 protease
176 - Superoxide generated via an activated NADPH oxidase causes uterine remodelling by orchestrating cell-surface interactions - is embryo implantation a superoxide affair?
185 - Endoplasmic Reticulum Oxidoreductin 1 Promotes Aberrant Lung Progenitor Cell Expansion and Lung Injury in Response to Infection with Influenza A in Mice
187 - Calcium-dependent Activation of Adenosine Monophosphate-activated Protein Kinase Regulates Sulfane Sulfur Production During Hypoxia in Endothelial Cells
191 - The Multifaceted Role of NOX4 in Pancreatic Beta Cell Function, Aging, and Pathology
Location: Congressional/Senate/South American
Speaker: Lydie Plecita – Insitute of Physiology, Czech Academy of Sciences
Redox/Cell Signaling
4:15 PM - 6:15 PM US EST
192 - Biochemical analysis of a Prx5-group peroxiredoxin-glutaredoxin hybrid protein expressed by Haemophilus parainfluenzae species within the oral microbiome
Location: Congressional/Senate/South American
Speaker: Leslie Poole – Wake Forest University School of Medicine
Redox/Cell Signaling
4:15 PM - 6:15 PM US EST
193 - Activity-based CO2 sensing in redox metabolism: studies using CarboSenR2
Location: Congressional/Senate/South American
Speaker: Rafael Radi, MD, PhD – Universidad de la Republica - Redox Biochemistry & Chemistry Editor in Chief
Redox/Cell Signaling
4:15 PM - 6:15 PM US EST
194 - Mechanism of Oxidants-Mediated Senescence Induction via Mitochondrial Damage in Lung Fibroblasts
195 - Oxidative medifications and inflammation in the anterior pituitary gland upon exposure to conditioned medium from splenic macrophages: An ex vivo experimental rat model of polycystic ovary syndrome
Location: Congressional/Senate/South American
Speaker: Dario C. Ramirez, PhD M.Sc. – National University of San Luis - National Bureau of Science and Technology-San Luis
Redox/Cell Signaling
4:15 PM - 6:15 PM US EST
196 - Miro1 expression and Subcellular Mitochondrial Positioning Impacts H2O2 Gradients and Receptor Tyrosine Kinase Expression in MEFs
207 - Integrative Study of Phytochemicals for Anti-Fibroid Agent: A Perspective on Protein Networks, Molecular Docking, ADMET, Simulation, DFT, and Bioactivity
Location: Congressional/Senate/South American
Speaker: Esther Kehinde – Federal University of Technology, Akure, Ondo state
Inflammation and Immunity
4:15 PM - 6:15 PM US EST
208 - Enhancing cannabinoid redox and immunomodulatory activity via bionanomaterial-based delivery system.
210 - KYC, a multimodal agent, and hE-HMGB1-BP, an apoE mimetic that targets HMGB1, improve hemorheology and reduce chronic lung injury via regulating sterile induction of immunological mechanisms
Location: Congressional/Senate/South American
Speaker: Tarun Pant – Medical College of Wisconsin
Inflammation and Immunity
4:15 PM - 6:15 PM US EST
211 - Loss of T-lymphocyte Hemoglobin Alpha Promotes Cellular and Mitochondrial Dysfunction
215 - Antioxidants Fail to Prevent Glucose Hypometabolism-Induced Neural Cell Death, Unlike Dimethyl-2-oxoglutarate: Implications in Alzheimer’s Disease
Location: Congressional/Senate/South American
Speaker: Aman Chauhan – Maharishi Markandeshwar Institute of Medical Sciences & Research, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala, Haryana, India
Neurodegenerative Disease
4:15 PM - 6:15 PM US EST
216 - Dual Role of NRF2 in Regulating Microglial Inflammation and Autophagy in Alzheimer’s Disease
Location: Congressional/Senate/South American
Speaker: Ching Tung Chu – Department of Biochemistry & Molecular Biology, Tohoku University, Tohoku Medical Megabank Organization
Neurodegenerative Disease
4:15 PM - 6:15 PM US EST
218 - Role of Histone Lysine Demethylase Family 4 In Vascular Contributions to Dementia
222 - Intranasal administration of plasma-extracellular vesicle-derived microRNA improves cognitive function in a mouse model of familial Alzheimer’s disease.
223 - The dual role of the Keap1/Nrf2/ARE system in the development of neurodegenerative diseases: An in vitro study
Location: Congressional/Senate/South American
Speaker: Elena Menshchikova – Federal Research Center for Fundamental and Translational Medicine
Neurodegenerative Disease
4:15 PM - 6:15 PM US EST
225 - Day-night oscillations in MPO, TNF alpha and clock-related factor expression are modified by an intracerebroventricular injection of AB peptide in the hippocampus of rats
Location: Congressional/Senate/South American
Speaker: Dario C. Ramirez, PhD M.Sc. – National University of San Luis - National Bureau of Science and Technology-San Luis
Neurodegenerative Disease
4:15 PM - 6:15 PM US EST
226 - Targeting Oxidative Stress in Neurodegeneration: Insights into Hordenine–Lactoferrin Interaction through In Silico and Spectroscopic Approaches
187 - Calcium-dependent Activation of Adenosine Monophosphate-activated Protein Kinase Regulates Sulfane Sulfur Production During Hypoxia in Endothelial Cells
222 - Intranasal administration of plasma-extracellular vesicle-derived microRNA improves cognitive function in a mouse model of familial Alzheimer’s disease.
