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4 - SYMPOSIUM SESSION: Linking Oxidative Stress and Senescence to Diseases

Thursday, November 20, 2025
2:15 PM - 4:15 PM US EST

Senescence has been implicated in the development of conditions such as cancer, neurodegenerative disorders, cardiovascular diseases, and metabolic disorders. Elevated levels of ROS, including superoxide and hydrogen peroxide, induce DNA damage, trigger cellular stress responses, epigenetic changes and activate signaling pathways leading to senescence. The intricate interplay between ROS and senescence highlights the complex relationship between cellular redox status and the regulation of many diseases, making these processes subjects of intense research in understanding potential therapeutic interventions.

Presentations:

  • 2:15 PM - 2:45 PM US EST
    Selenium, Senescence and Cancer Inhibition

    Speaker: J. Andres Melendez, PhD (he/him/his) – University at Albany, USA

  • 2:45 PM - 3:15 PM US EST
    Senescence as a Driver of Aging and Acute Injury

    Speaker: Raghavan Raju, PhD (he/him/his) – Medical College of Georgia, USA

  • 3:15 PM - 3:35 PM US EST
    Dual-Phase Role of Irradiated Adipocytes in Promoting Breast Cancer Cell Migration

    Oral Presenter: Liu Mei, PhD – University of Nebraska Medical Center

  • 3:35 PM - 3:55 PM US EST
    Glutaredoxin status regulates cellular senescence in aged lung fibroblasts in association with S-glutathionylation of P16INK4a

    Oral Presenter: Hend Abdelhamid, PhD (she/her/hers) – University of Vermont

  • 3:55 PM - 4:15 PM US EST
    Targeting Oxidative Stress–Associated Vascular Senescence in Premature Aging with Novel mTOR Inhibitors Identified by Multi-Omics Discovery Platform

    Oral Presenter: Perinur Bozaykut – Tufts University